Liquid Scintillation 14C Spectrometry: Errors and Assurances

Determination of chemical and radiochemical purity of [14C] clozapine by high performance liquid chromatography and liquid scintillation [Persian]

Introduction: The mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. The effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. To further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14C] clozapine with suita...

Liquid-Scintillation Counting of 14C-Labelled Animal Tissues

Developments of liquid-scintillation counting as a practical method for the assay of radioisotopes in biological samples followed work by Reynolds, Harrison & Salvini (1950) and Kailmann & Furst (1950). Reviews of progress and developments in liquid-scintillation counting have been given by Davidson & Fiegelson (1957) and Bell & Hayes (1958). Guinn (1958) and Stitch (1959) have reviewed the adv...

Analytical performance of accelerator mass spectrometry and liquid scintillation counting for detection of 14C-labeled atrazine metabolites in human urine.

Accelerator mass spectrometry (AMS) has been applied to the detection of 14C-labeled urinary metabolites of the triazine herbicide, atrazine, and the analytical performance of AMS has been directly compared to that of liquid scintillation counting (LSC). Ten human subjects were given a dermal dose of 14C-labeled atrazine over 24 h, and urine from the subjects was collected over a 7-day period. ...

determination of chemical and radiochemical purity of [14c] clozapine by high performance liquid chromatography and liquid scintillation [persian]

introduction: the mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. the effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. to further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14c] clozapine with suitable ra...

High resolution neutron spectrometry with liquid scintillation detectors